Glucose-Insulin-Potassium Revived
نویسندگان
چکیده
منابع مشابه
Glucose-insulin-potassium revived: current status in acute coronary syndromes and the energy-depleted heart.
T he oxidative metabolism of the human heart was first defined by Bing and colleagues 1 in a series of articles in the 1950s. Carbohydrates made up a relatively small part of the oxidative metabolism of the resting human heart. Focus on free fatty acids (FFAs) as a major myocardial fuel started with the finding in 1961 that FFAs inhibited glucose oxidation in the isolated heart. 2 The next year...
متن کاملEffect of Glucose-Insulin-Potassium Infusion
The effects of glucose-insulin-potassium (GIK) infusion and glucose (G) infusion started 30 min after experimental coronary occlusion and the combination of GIK and propranolol (P) started 3 hours after coronary occlusion on the development of myocardial infarction were studied in 37 dogs. Fifteen minutes after the coronary occlusion, epicardial electrocardiograms were recorded at 10-15 sites; ...
متن کاملThe Protective Effect of Glucose-Insulin-Potassium
1. Gaffney TE, Sigell LT, Mohammed S, Atkinson AJ: The clinical pharmacology of antihypertensive drugs. Prog Cardiovas Dis 12: 52, 1969 2. Oates JA, Mitchell JR, Feagin OT, Kaufmann JS, Shand DG: Distribution of guanidinium antihypertensives mechanism of their selective action. Ann NY Acad Sci 197: 302, 1971 3. Nickerson M, Ruedy J: Antihypertensive agents and the drug therapy of hypertension. ...
متن کاملGlucose, insulin and potassium for heart protection during cardiac surgery.
BACKGROUND Coronary artery bypass grafting with hypothermic cardiac arrest and cardiopulmonary bypass (CPB) is associated with myocardial injury. Our study investigated whether an infusion of glucose, insulin and potassium (GIK) during elective coronary artery bypass surgery decreases myocardial cell death. METHODS We measured cardiac troponin I (cTnI), a myofibrillar structural protein, whic...
متن کاملBlock of Kv1.7 potassium currents increases glucose-stimulated insulin secretion
Glucose-stimulated insulin secretion (GSIS) relies on repetitive, electrical spiking activity of the beta cell membrane. Cyclic activation of voltage-gated potassium channels (K(v) ) generates an outward, 'delayed rectifier' potassium current, which drives the repolarizing phase of each spike and modulates insulin release. Although several K(v) channels are expressed in pancreatic islets, thei...
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ژورنال
عنوان ژورنال: Circulation
سال: 2013
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.112.130625